How animate div with tons of dom objects inside?

I’ve found a lot of animation scripts (jQuery, etc) that all work perfectly for animating a DIV with some text or an image inside. However, if the DIV has hundreds of divs, each with 20 or so span objects inside them, the animation doesn’t work. It becomes jumpy and too heavy a load on the GPU or processor. I haven’t been able to get animation like this to work anywhere. Does anyone know of a solution?

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